• By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c),
pN2a, pN2b, pN3a, or pN3b.
• If pN0, tumor must be > 3.0 cm.
Note: If ALT is performed instead of AST (per institution's standard practice), the ALT value
must be ≤ 1.5 x ULN; if both were performed, the AST must be ≤ 1.5 x ULN.
Active cardiac disease
History of cardiac disease
Doxorubicin (A) + Cyclophosphamide (C) IV every 2 weeks (dose-dense) x 4 cycles
initiate 2-3 weeks after the last dose of AC
Paclitaxel (WP) IV weekly x 12 doses
Paclitaxel (WP) IV weekly x 12 doses + Carboplatin IV every 21 days x 4 cycles