Clinical Trials

Clinical research plays a vital role in the war on cancer.  Through research we discover new and better ways to fight this disease, improve the quality of life for patients, and ultimately one day, to prevent cancer.  Research studies, also called clinical trials or protocols, help develop better treatments to improve survival, understand how cancer grows and manage side effects of treatment to improve quality of life. 
Pearlman offers clinical trials sponsored by the National Cancer Institute as well as pharmaceutical companies.

Precision Medicine

There has been a lot of interest in recent years in refining the strategy for treating chronic or life-threatening diseases using more precise means of targeting the driver of the illness. In cancer, we’re examining the molecular environment and genetic code of tumors to identify abnormalities that can be eliminated or altered by a drug. Pearlman Cancer Center is opening a series of trials through the National Cancer Institute’s Precision Medicine Initiative that will offer patients with advanced cancers an opportunity to benefit from this innovative strategy.

The Lung-MAP Study (SWOG 1400) is the first of these trials, and it consists of several sub-studies within the larger umbrella trial. New sub-studies will be added as new potential targets are identified for exploration in squamous cell lung cancer. ALCHEMIST and the Exceptional Responders Initiative are also open. ALCHEMIST examines the usefulness of drugs that target two specific abnormalities in early stage lung cancer that has been surgically removed. Normally these drugs (erlotinib and crizotinib) are reserved for patients with more advanced disease. The Exceptional Responders Initiative is unique in that it looks back at patients who had unexpected and durable responses to treatment – what was unique about their cancers that allowed them to have such an extraordinary response? Can we exploit that finding to benefit future patients? The most recent trial to open is NCI-MATCH, which gives patients with advanced disease an opportunity to be treated with novel agents that target specific mutations or markers identified in their tumors.

This is an exciting time in cancer research as we discover how to use the unique biology of the patient’s tumor to fight these difficult cancers.

Clinical Trials: Protocols Available by Disease Site


SWOG 0931
EVEREST:  EVErolimus for Renal Cancer Ensuing Surgical Therapy, A Phase III Study



(ALCHEMIST) Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial. A screening trial for A081105 and E4512.

(An ALCHEMIST sub-study) A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

(An ALCHEMIST sub-study) Randomized Double Blind Placebo Controlled Study of Erlotinib or Placebo in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Lung Cancer (NSCLC)


SWOG 1400
Phase II/III Biomarker-Driven Master Protocol for Second Line Therapy of Squamous Cell Lung Cancer

Solid Tumors


SWOG EAY 131 - MATCH (Molecular Analysis for Therapy Choice)
Study investigates whether tumors with mutations, amplifications or translocations in one of the genetic pathways of interest are likely to derive benefit from drugs that target that specific pathway.  Designed for patients with progressive disease or for whom no standard therapy exists.

The following disease sites have no studies available at this time: Breast,  Colon, Gallbladder, Genitourinary, GIST, Head and Neck, Leukemia, Lymphoma, Melanoma, Myeloma, Pancreas and Prostate.